Mining cancer gene expression databases for latent information on intronic microRNAs
نویسندگان
چکیده
منابع مشابه
Mining gene expression databases for association rules
MOTIVATION Global gene expression profiling, both at the transcript level and at the protein level, can be a valuable tool in the understanding of genes, biological networks, and cellular states. As larger and larger gene expression data sets become available, data mining techniques can be applied to identify patterns of interest in the data. Association rules, used widely in the area of market...
متن کاملIntronic microRNAs: a crossroad in gene regulation.
Most human genes transcribed by RNA Pol II (polymerase II) contain short exons separated by long tracts of non-coding intronic sequences. In addition to their role in generating proteomic diversity through the process of alternative splicing, intronic sequences host many ncRNAs (non-coding RNAs), involved in various gene regulation processes. miRNAs (microRNAs) are short ncRNAs that mediate eit...
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The DNA microarray technology has arguably caught the attention of the worldwide life science community and is now systematically supporting major discoveries in many fields of study. The majority of the initial technical challenges of conducting experiments are being resolved, only to be replaced with new informatics hurdles, including statistical analysis, data visualization, interpretation, ...
متن کاملProcessing of intronic microRNAs.
The majority of human microRNA (miRNA) loci are located within intronic regions and are transcribed by RNA polymerase II as part of their hosting transcription units. The primary transcripts are cleaved by Drosha to release approximately 70 nt pre-miRNAs that are subsequently processed by Dicer to generate mature approximately 22 nt miRNAs. It is generally believed that intronic miRNAs are rele...
متن کاملGene Expression Data Mining for Cancer Detection
Cancer is getting constantly challenged by many eminent and premier researchers. Due to advanced developments in instrumentation, it has become easier to collect a lot of experimental data in molecular biology. Analysis of such data is very vital as it leads to knowledge discovery that can further be validated by experiments. It has been used multiple times for cancer classification and of iden...
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ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2014
ISSN: 1574-7891
DOI: 10.1016/j.molonc.2014.10.001